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陆军军医大学 Army Medical University
研究员 Professor
谌小维研究员分别于2004年、2007年获第三军医大学临床医学学士和硕士学位,2008至2013年在德国慕尼黑工业大学获得神经科学博士学位并进行博士后研究,2013年至今在第三军医大学基础医学院脑科学研究室担任主任/研究员/博士生导师,2020年起担任中科院脑与智能卓越创新中心骨干。
谌小维研究员长期从事大脑微尺度皮层感觉信息处理机制研究,近年来在信息记忆、运动输出等发生机制以及光学成像技术,生物脑启发的智能技术等方面取得了突出成绩。是国家高层次青年人才计划(2012),国家科技部青年973项目(2015),国家自然基金委中国-以色列科学基金合作项目(2018),国家杰出青年基金(2019)以及国家重大科研仪器研制项目(2021)的获得者。在Nature、Science、Nature Neuroscience、Neuron、PNAS等杂志发表论文70余篇,单篇最高引用超过520次,总引用率超过4200次。成果“皮层星形胶质细胞尼古丁受体介导记忆维持”入选2021中国神经科学十大进展。
Xiaowei Chen, Ph. D., Professor. He received his Bachelor's and Master's degrees in Clinical Medicine from the Third Military Medical University in 2004 and 2007, respectively. From 2008 to 2013, he obtained his Ph.D. degree in neuroscience from the Technical University of Munich in Germany and conducted postdoctoral research there. Since 2013, Dr. Chen has been the Director/Professor at the Brain Research Center at the School of Basic Medicines, Third Military Medical University. Since 2020, he has also been a member of the Brain and Intelligence Advanced Innovation Center at the Chinese Academy of Sciences. Dr. Chen has made contributions to understanding the mechanisms underlying sensory information processing and memory. Dr. Chen has published over 70 papers in scientific journals such as Nature, Science, Nature Neuroscience, Neuron, and PNAS.
报告题目:
Brain cells and circuits for memory
报告摘要:
We investigate cellular and circuit mechanisms underlying memory formation, consolidation, and persistence at multiple scales from synapses to single neurons to networks. At the cellular level, we identified a population of sparsely distributed neurons in the auditory cortex that exhibited a stable response pattern of high-frequency burst firing to the learned sounds. These cells are termed holistic bursting cells, which have been suggested to be the basis of the memory of the learned sounds in the auditory cortex. Moreover, we found that fear learning-induced a newly developed and nicotinic receptor-mediated signal in cortical astrocytes, which plays an important role in memory persistence. At the circuit level, we found that the medial entorhinal cortex layer II-dentate gyrus pathway exhibited a task-dependent persistent activity developed over spatial learning, and we identified the importance of the hypothalamic supramammillary nucleus-hippocampal CA2 pathway for social memory consolidation during rapid eye movement sleep. Therefore, we have partially dissected memory mechanisms by investigating cellular and circuit mechanisms of memory formation, consolidation, and maintenance in the sensory cortex-entorhinal cortex-hippocampus-neocortex system.
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谌小维研究员分别于2004年、2007年获第三军医大学临床医学学士和硕士学位,2008至2013年在德国慕尼黑工业大学获得神经科学博士学位并进行博士后研究,2013年至今在第三军医大学基础医学院脑科学研究室担任主任/研究员/博士生导师,2020年起担任中科院脑与智能卓越创新中心骨干。
谌小维研究员长期从事大脑微尺度皮层感觉信息处理机制研究,近年来在信息记忆、运动输出等发生机制以及光学成像技术,生物脑启发的智能技术等方面取得了突出成绩。是国家高层次青年人才计划(2012),国家科技部青年973项目(2015),国家自然基金委中国-以色列科学基金合作项目(2018),国家杰出青年基金(2019)以及国家重大科研仪器研制项目(2021)的获得者。在Nature、Science、Nature Neuroscience、Neuron、PNAS等杂志发表论文70余篇,单篇最高引用超过520次,总引用率超过4200次。成果“皮层星形胶质细胞尼古丁受体介导记忆维持”入选2021中国神经科学十大进展。
Xiaowei Chen, Ph. D., Professor. He received his Bachelor's and Master's degrees in Clinical Medicine from the Third Military Medical University in 2004 and 2007, respectively. From 2008 to 2013, he obtained his Ph.D. degree in neuroscience from the Technical University of Munich in Germany and conducted postdoctoral research there. Since 2013, Dr. Chen has been the Director/Professor at the Brain Research Center at the School of Basic Medicines, Third Military Medical University. Since 2020, he has also been a member of the Brain and Intelligence Advanced Innovation Center at the Chinese Academy of Sciences. Dr. Chen has made contributions to understanding the mechanisms underlying sensory information processing and memory. Dr. Chen has published over 70 papers in scientific journals such as Nature, Science, Nature Neuroscience, Neuron, and PNAS.
报告题目:
Brain cells and circuits for memory
报告摘要:
We investigate cellular and circuit mechanisms underlying memory formation, consolidation, and persistence at multiple scales from synapses to single neurons to networks. At the cellular level, we identified a population of sparsely distributed neurons in the auditory cortex that exhibited a stable response pattern of high-frequency burst firing to the learned sounds. These cells are termed holistic bursting cells, which have been suggested to be the basis of the memory of the learned sounds in the auditory cortex. Moreover, we found that fear learning-induced a newly developed and nicotinic receptor-mediated signal in cortical astrocytes, which plays an important role in memory persistence. At the circuit level, we found that the medial entorhinal cortex layer II-dentate gyrus pathway exhibited a task-dependent persistent activity developed over spatial learning, and we identified the importance of the hypothalamic supramammillary nucleus-hippocampal CA2 pathway for social memory consolidation during rapid eye movement sleep. Therefore, we have partially dissected memory mechanisms by investigating cellular and circuit mechanisms of memory formation, consolidation, and maintenance in the sensory cortex-entorhinal cortex-hippocampus-neocortex system.