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北京脑科学与类脑研究中心 Chinese Institute for Brain Research, Beijing (CIBR)
资深研究员
Akihiro Yamanaka 北京脑科学与类脑研究中心,资深研究员。
-教育经历
1994 日本静冈县立大学,药学学士
1996 日本静冈县立大学,药理学硕士
2000 日本筑波大学,药理学博士
-工作经历
2022至今 北京脑科学与类脑研究中心,资深研究员
2012-2022 日本名古屋大学环境医学研究所(RIEM),教授
2008 日本国立生理学研究所(NIPS),副教授
2006 美国耶鲁大学,客座研究员
2002 日本筑波大学基础医学院药理学系,助理教授
2000 日本筑波大学基础医学院药理学系,研究助理
-荣誉、奖励、学术兼职
2018-2020 日本科学技术振兴机构CREST研究员
2009-2013 日本科学技术振兴机构PRESTO研究员
2005 筑波大学最佳教师奖
2003 APSS青年科学家奖
-研究概述
下丘脑通过合成与释放神经肽调控动物本能行为,如进食行为、睡眠/觉醒行为、性行为等。实验室借助分子生物学、组织化学、电生理学、行为药理学和光遗传学等研究手段,重点关注下丘脑肽能神经元及其对本能行为的调节机制。
-发表文章
1. Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takikawa H, Tsunoda SP, Horigane S, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, *Yamashita T: Remote control of neural function by X-ray-induced scintillation. Nat Commun, 2(1):4478 (2021).
2. *Ono D, Mukai Y, Hung CJ, Chowdhury S, Sugiyama T, *Yamanaka A: The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus. Science Advances, 6(45):eabd0384 (2020).
3. Hung CJ, Ono D, Kilduff TS, *Yamanaka A: Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy. eLife, 9:e54275 (2020).
4. Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, *Yamanaka A: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories. Science, 365: 1308-1313 (2019).
5. Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, *Yamanaka A: Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice. eLife, 8: e44927 (2019a).
6. Chowdhury S, Matsubara T, Miyazaki T, Ono D, Fukatsu N, Abe M, Sakimura K, Sudo Y, *Yamanaka A: GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice. eLife, 8: e44928 (2019b).
-Educational Experience
1994 B.S. in Pharmacy, University of Shizuoka
1996 M.S. in Pharmacology, University of Shizuoka
2000 Ph.D. in Pharmacology, University of Tsukuba
-Professional Experience
2000 Research Assistant at the Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
2002 Assistant Professor at the Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
2006 Visiting Researcher, Yale University, USA
2008 Associate Professor, National Institute of Physiological Sciences (NIPS), Japan
2012-2022 Professor, Research Institute of Environmental Medicine (RIEM), Nagoya University, Japan
2022- Investigator, Chinese Institute for Brain Research, Beijing
-Honors, Awards and Adjunct Research Positions
2003 Young Investigator’s Award, APSS
2005 Best teacher’s award, University of Tsukuba
2009-2013 Researcher at PRESTO, Japan Science and Technology Agency (JST)
2018-2020 Researcher at CREST, Japan Science and Technology Agency (JST)
-Research Description
Instinctive behaviors, such as feeding behavior, sleep/wakefulness and sexual behavior, are mainly regulated by the hypothalamic neurons which synthesize and release neuropeptide as a neurotransmitter. We are focusing on these peptide-producing neurons and studying the regulatory mechanisms of instinctive behaviors by using the following approaches, molecular biology, histochemistry, electrophysiology, behavioral pharmacology and optogenetics.
-Publications
1. Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takikawa H, Tsunoda SP, Horigane S, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, *Yamashita T: Remote control of neural function by X-ray-induced scintillation. Nat Commun, 2(1):4478 (2021).
2. *Ono D, Mukai Y, Hung CJ, Chowdhury S, Sugiyama T, *Yamanaka A: The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus. Science Advances, 6(45):eabd0384 (2020).
3. Hung CJ, Ono D, Kilduff TS, *Yamanaka A: Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy. eLife, 9:e54275 (2020).
4. Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, *Yamanaka A: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories. Science, 365: 1308-1313 (2019).
5. Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, *Yamanaka A: Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice. eLife, 8: e44927 (2019a).
6. Chowdhury S, Matsubara T, Miyazaki T, Ono D, Fukatsu N, Abe M, Sakimura K, Sudo Y, *Yamanaka A: GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice. eLife, 8: e44928 (2019b).
报告题目:
Activity dynamics of orexin/hypocretin neurons and their role in the regulation of sleep/wakefulness
{{subItem.subtitle}}
Akihiro Yamanaka 北京脑科学与类脑研究中心,资深研究员。
-教育经历
1994 日本静冈县立大学,药学学士
1996 日本静冈县立大学,药理学硕士
2000 日本筑波大学,药理学博士
-工作经历
2022至今 北京脑科学与类脑研究中心,资深研究员
2012-2022 日本名古屋大学环境医学研究所(RIEM),教授
2008 日本国立生理学研究所(NIPS),副教授
2006 美国耶鲁大学,客座研究员
2002 日本筑波大学基础医学院药理学系,助理教授
2000 日本筑波大学基础医学院药理学系,研究助理
-荣誉、奖励、学术兼职
2018-2020 日本科学技术振兴机构CREST研究员
2009-2013 日本科学技术振兴机构PRESTO研究员
2005 筑波大学最佳教师奖
2003 APSS青年科学家奖
-研究概述
下丘脑通过合成与释放神经肽调控动物本能行为,如进食行为、睡眠/觉醒行为、性行为等。实验室借助分子生物学、组织化学、电生理学、行为药理学和光遗传学等研究手段,重点关注下丘脑肽能神经元及其对本能行为的调节机制。
-发表文章
1. Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takikawa H, Tsunoda SP, Horigane S, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, *Yamashita T: Remote control of neural function by X-ray-induced scintillation. Nat Commun, 2(1):4478 (2021).
2. *Ono D, Mukai Y, Hung CJ, Chowdhury S, Sugiyama T, *Yamanaka A: The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus. Science Advances, 6(45):eabd0384 (2020).
3. Hung CJ, Ono D, Kilduff TS, *Yamanaka A: Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy. eLife, 9:e54275 (2020).
4. Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, *Yamanaka A: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories. Science, 365: 1308-1313 (2019).
5. Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, *Yamanaka A: Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice. eLife, 8: e44927 (2019a).
6. Chowdhury S, Matsubara T, Miyazaki T, Ono D, Fukatsu N, Abe M, Sakimura K, Sudo Y, *Yamanaka A: GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice. eLife, 8: e44928 (2019b).
-Educational Experience
1994 B.S. in Pharmacy, University of Shizuoka
1996 M.S. in Pharmacology, University of Shizuoka
2000 Ph.D. in Pharmacology, University of Tsukuba
-Professional Experience
2000 Research Assistant at the Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
2002 Assistant Professor at the Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
2006 Visiting Researcher, Yale University, USA
2008 Associate Professor, National Institute of Physiological Sciences (NIPS), Japan
2012-2022 Professor, Research Institute of Environmental Medicine (RIEM), Nagoya University, Japan
2022- Investigator, Chinese Institute for Brain Research, Beijing
-Honors, Awards and Adjunct Research Positions
2003 Young Investigator’s Award, APSS
2005 Best teacher’s award, University of Tsukuba
2009-2013 Researcher at PRESTO, Japan Science and Technology Agency (JST)
2018-2020 Researcher at CREST, Japan Science and Technology Agency (JST)
-Research Description
Instinctive behaviors, such as feeding behavior, sleep/wakefulness and sexual behavior, are mainly regulated by the hypothalamic neurons which synthesize and release neuropeptide as a neurotransmitter. We are focusing on these peptide-producing neurons and studying the regulatory mechanisms of instinctive behaviors by using the following approaches, molecular biology, histochemistry, electrophysiology, behavioral pharmacology and optogenetics.
-Publications
1. Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takikawa H, Tsunoda SP, Horigane S, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, *Yamashita T: Remote control of neural function by X-ray-induced scintillation. Nat Commun, 2(1):4478 (2021).
2. *Ono D, Mukai Y, Hung CJ, Chowdhury S, Sugiyama T, *Yamanaka A: The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus. Science Advances, 6(45):eabd0384 (2020).
3. Hung CJ, Ono D, Kilduff TS, *Yamanaka A: Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy. eLife, 9:e54275 (2020).
4. Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, *Yamanaka A: REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories. Science, 365: 1308-1313 (2019).
5. Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, *Yamanaka A: Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice. eLife, 8: e44927 (2019a).
6. Chowdhury S, Matsubara T, Miyazaki T, Ono D, Fukatsu N, Abe M, Sakimura K, Sudo Y, *Yamanaka A: GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice. eLife, 8: e44928 (2019b).
报告题目:
Activity dynamics of orexin/hypocretin neurons and their role in the regulation of sleep/wakefulness