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复旦大学脑科学转化研究院 副院长 Institute for Translational Brain Research, Fudan University
教授 Professor
郭非凡,复旦大学教授,国家重点研发项目首席科学家,“国家高层次人才”、“国务院政府特殊津贴”获得者,“上海市领军人才”、“上海市优秀学术带头人”入选者,获“上海市巾帼创新奖”、“上海市三八红旗手标兵”等称号。2001年毕业于日本东京大学,获脑神经医学博士学位;2001-2002年和2002-2005年先后在美国明尼苏达州立大学、哈佛大学医学院Beth Israel Deaconess医学中心接受博士后训练;2005-2007年在美国宾州州立大学生物系担任助理研究教授;2007-2022年在中国科学院上海生命科学研究院和中国科学院上海营养与健康研究所先后任研究员、中科院营养代谢与食品安全重点实验室主任; 2022年2月全职加入复旦大学脑科学转化研究院任复旦大学教授、脑转院副院长。获科技部国家重点研发项目、国家杰出青年基金、基金委重点项目、基金委重大研究计划项目、上海市领军人才、学术带头人、浦江人才计划等项目的资助。获国务院政府特殊津贴、上海市巾帼创新奖、三八红旗手标兵、三八红旗手等荣誉。致力于代谢性疾病发生发展的营养感应与神经调控机制,创新性提出氨基酸是调控机体能量和糖脂代谢的关键信号分子。原创性研究工作发表在Cell Metabolism、Nature Communications、Gastroenterology、Diabetes (14篇)、Diabetologia、Autophagy等学术期刊上。
Dr. Guo is a professor and vice president at the Institute for Translational Brain Research (ITBR), Fudan University. Dr. Guo obtained her Ph.D. in Neuroscience from the University of Tokyo in 2001. After that, she did postdoc training at Department of Psychiatry, University of Minnesota (2001-2002), and Division of Endocrinology, Beth Israel Deaconess Medical Center at Harvard Medical School (2002-2005). Then she worked as a Research Assistant Professor at Department of Biology, the Pennsylvania State University. In 2007, she established her lab and worked as a Professor and Principal Investigator in Shanghai Institute of Nutrition and Health, Chinese Academy of Science (CAS). She was also a director of the Key Lab of Nutrition, Metabolism and Food Safety of CAS. In 2022, she joined Fudan University. Dr. Guo has been supported by grants from National Key R&D Program of China, National Science Foundation for Distinguished Young Scholars, the Key Program of National Natural Science Foundation of China (NSFC), and the Major Research Plan of NSFC. Dr. Guo has been awarded State Council Government Special Allowance, Shanghai Leading Talents, Shanghai Excellent Academic Leader, Shanghai Women's Innovation Award, and the title of March 8 Red-banner pacesetter. As a corresponding author, Dr. Guo has published over 40 papers, including in Gastroenterology, Nature Communications, Autophagy and 14 in Diabetes.
报告题目:
中枢营养感应与代谢性疾病
Central nutrient sensing and metabolism control
报告摘要:
机体通过多种器官组织的协同互作来维持代谢稳态,其中环节出现异常会导致代谢紊乱及代谢性疾病。神经中枢在此起至关重要的作用。一方面可以感觉营养、激素等变化,通过神经及内分泌系统来调控外周代谢;另一方面可响应来自外周组织的细胞因子、分泌蛋白及神经相关信号的变化。但相关机理并不清楚,严重阻碍代谢性疾病的防治,因而迫切需要深入研究。探讨中枢和外周组织协同调控代谢机理,将对代谢性疾病防治提供重要理论基础和新型药物靶标。
The crosstalk between multiple organs if required for the maintainance of the metabolic homeostasis, and the brain is the center for the regulation. The brain senses the changes of nutrients, hormone, etc, thereby regulating the metabolism via neuroendocrine system; on the other hand, it receives signals from peripheral tissues. However, the mechanisms are poorly understood. Elucidating the mechanisms underlying central control of metabolism will help for the treatment of metabolic diseases.
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郭非凡,复旦大学教授,国家重点研发项目首席科学家,“国家高层次人才”、“国务院政府特殊津贴”获得者,“上海市领军人才”、“上海市优秀学术带头人”入选者,获“上海市巾帼创新奖”、“上海市三八红旗手标兵”等称号。2001年毕业于日本东京大学,获脑神经医学博士学位;2001-2002年和2002-2005年先后在美国明尼苏达州立大学、哈佛大学医学院Beth Israel Deaconess医学中心接受博士后训练;2005-2007年在美国宾州州立大学生物系担任助理研究教授;2007-2022年在中国科学院上海生命科学研究院和中国科学院上海营养与健康研究所先后任研究员、中科院营养代谢与食品安全重点实验室主任; 2022年2月全职加入复旦大学脑科学转化研究院任复旦大学教授、脑转院副院长。获科技部国家重点研发项目、国家杰出青年基金、基金委重点项目、基金委重大研究计划项目、上海市领军人才、学术带头人、浦江人才计划等项目的资助。获国务院政府特殊津贴、上海市巾帼创新奖、三八红旗手标兵、三八红旗手等荣誉。致力于代谢性疾病发生发展的营养感应与神经调控机制,创新性提出氨基酸是调控机体能量和糖脂代谢的关键信号分子。原创性研究工作发表在Cell Metabolism、Nature Communications、Gastroenterology、Diabetes (14篇)、Diabetologia、Autophagy等学术期刊上。
Dr. Guo is a professor and vice president at the Institute for Translational Brain Research (ITBR), Fudan University. Dr. Guo obtained her Ph.D. in Neuroscience from the University of Tokyo in 2001. After that, she did postdoc training at Department of Psychiatry, University of Minnesota (2001-2002), and Division of Endocrinology, Beth Israel Deaconess Medical Center at Harvard Medical School (2002-2005). Then she worked as a Research Assistant Professor at Department of Biology, the Pennsylvania State University. In 2007, she established her lab and worked as a Professor and Principal Investigator in Shanghai Institute of Nutrition and Health, Chinese Academy of Science (CAS). She was also a director of the Key Lab of Nutrition, Metabolism and Food Safety of CAS. In 2022, she joined Fudan University. Dr. Guo has been supported by grants from National Key R&D Program of China, National Science Foundation for Distinguished Young Scholars, the Key Program of National Natural Science Foundation of China (NSFC), and the Major Research Plan of NSFC. Dr. Guo has been awarded State Council Government Special Allowance, Shanghai Leading Talents, Shanghai Excellent Academic Leader, Shanghai Women's Innovation Award, and the title of March 8 Red-banner pacesetter. As a corresponding author, Dr. Guo has published over 40 papers, including in Gastroenterology, Nature Communications, Autophagy and 14 in Diabetes.
报告题目:
中枢营养感应与代谢性疾病
Central nutrient sensing and metabolism control
报告摘要:
机体通过多种器官组织的协同互作来维持代谢稳态,其中环节出现异常会导致代谢紊乱及代谢性疾病。神经中枢在此起至关重要的作用。一方面可以感觉营养、激素等变化,通过神经及内分泌系统来调控外周代谢;另一方面可响应来自外周组织的细胞因子、分泌蛋白及神经相关信号的变化。但相关机理并不清楚,严重阻碍代谢性疾病的防治,因而迫切需要深入研究。探讨中枢和外周组织协同调控代谢机理,将对代谢性疾病防治提供重要理论基础和新型药物靶标。
The crosstalk between multiple organs if required for the maintainance of the metabolic homeostasis, and the brain is the center for the regulation. The brain senses the changes of nutrients, hormone, etc, thereby regulating the metabolism via neuroendocrine system; on the other hand, it receives signals from peripheral tissues. However, the mechanisms are poorly understood. Elucidating the mechanisms underlying central control of metabolism will help for the treatment of metabolic diseases.