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日本理化学研究所脑科学研究中心 神经环路和行为生理学团队负责人 RIKEN Center for Brain Science, Japan
教授 Professor
Professor Thomas McHugh majored in molecular and cellular biology at the University of California, Berkeley, before moving to the Massachusetts Institute of Technology (MIT) where he finished a PhD in biology. At MIT, he studied genetics and the physiology of spatial memory with Matt Wilson and Susumu Tonegawa, and continued to study the circuits of hippocampal memory as part of his postdoctoral studies. In 2009, he moved to what is now known as the RIKEN Center for Brain Science to start his own laboratory. His Laboratory for Circuit and Behavioral Physiology at RIKEN takes a multidisciplinary approach to understanding how memories are formed, stored and recalled in the mammalian brain, and how damage from factors such as stress and disease impair these functions. He combines in vivo hippocampal electrophysiology and cutting-edge conditional genetics to address research questions at a high level of precision. He is expert in manipulating plasticity, synaptic transmission or neuronal excitability in a subregion or pathway specific manner, and characterizing the consequences of those manipulations on the behavioral and physiological level. Thomas McHugh received Nakaakira Tsukahara Memorial Award, Brain Science Foundation in 2019 and NARSAD Young Investigator Award in 2010. Thomas McHugh has published multiple high-quality publications in journals such as Nature, Science and Cell.
报告题目:
Subcortical modulation of hippocampal memory
报告摘要:
The human hippocampus plays a crucial role in episodic memory; the who, what, where memories that define our lives. In the rodent, well-defined anatomy and physiology make the structure an ideal model system; amenable to circuit manipulations and observations designed to test hypotheses concerning how memories are formed and used. Here I will present our recent work in mice which combines anatomical characterization, genetic interventions and in vivo recording to address how noncononical inputs and outputs influence information flow in the hippocampus. I will first introduce our study identifying a novelty signaling hub in the hypothalamus – the supramammillary nucleus (SuM). Unique about this region is that it not only responds broadly to novel stimuli, but segregates and selectively routes different types of information to discrete cortical targets, the dentate gyrus (DG) and CA2 fields of the hippocampus, for the modulation of mnemonic processing. Next, I will describe ongoing work focused on how CA2’s output impacts both local and distal circuits, including our identification and characterization of a novel descending glutamatergic projection from CA2 pyramidal cells to PV+ neurons in the MS that can regulate cholinergic tone and hippocampal memory.
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Professor Thomas McHugh majored in molecular and cellular biology at the University of California, Berkeley, before moving to the Massachusetts Institute of Technology (MIT) where he finished a PhD in biology. At MIT, he studied genetics and the physiology of spatial memory with Matt Wilson and Susumu Tonegawa, and continued to study the circuits of hippocampal memory as part of his postdoctoral studies. In 2009, he moved to what is now known as the RIKEN Center for Brain Science to start his own laboratory. His Laboratory for Circuit and Behavioral Physiology at RIKEN takes a multidisciplinary approach to understanding how memories are formed, stored and recalled in the mammalian brain, and how damage from factors such as stress and disease impair these functions. He combines in vivo hippocampal electrophysiology and cutting-edge conditional genetics to address research questions at a high level of precision. He is expert in manipulating plasticity, synaptic transmission or neuronal excitability in a subregion or pathway specific manner, and characterizing the consequences of those manipulations on the behavioral and physiological level. Thomas McHugh received Nakaakira Tsukahara Memorial Award, Brain Science Foundation in 2019 and NARSAD Young Investigator Award in 2010. Thomas McHugh has published multiple high-quality publications in journals such as Nature, Science and Cell.
报告题目:
Subcortical modulation of hippocampal memory
报告摘要:
The human hippocampus plays a crucial role in episodic memory; the who, what, where memories that define our lives. In the rodent, well-defined anatomy and physiology make the structure an ideal model system; amenable to circuit manipulations and observations designed to test hypotheses concerning how memories are formed and used. Here I will present our recent work in mice which combines anatomical characterization, genetic interventions and in vivo recording to address how noncononical inputs and outputs influence information flow in the hippocampus. I will first introduce our study identifying a novelty signaling hub in the hypothalamus – the supramammillary nucleus (SuM). Unique about this region is that it not only responds broadly to novel stimuli, but segregates and selectively routes different types of information to discrete cortical targets, the dentate gyrus (DG) and CA2 fields of the hippocampus, for the modulation of mnemonic processing. Next, I will describe ongoing work focused on how CA2’s output impacts both local and distal circuits, including our identification and characterization of a novel descending glutamatergic projection from CA2 pyramidal cells to PV+ neurons in the MS that can regulate cholinergic tone and hippocampal memory.