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军事科学院军事医学研究院微生物流行病研究所 Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, China
研究员 Research Fellow
杨瑞馥,博士,军事医学科学院微生物流行病研究所研究员,国家自然科学基金杰出青年基金获得者。主要从事细菌菌基因组学、进化与致病机制和微生物法医学基础数据库的研究,以及检验新技术的研究。近年来,在New England Journal of Medicine、Science、Nature Genetics、Cell Metabolism,PNAS、CID、MBE等杂志发表学术SCI论文300余篇,被引27000余次,H因子72 (Google Scholar);担任《Zoonoses》、《微生物学学报》、《人兽共患病学报》和《中华预防医学杂志》副主编;近年来,获国家科技发明二等奖一项,并已成功转化。
Dr. Ruifu Yang, professor, from Beijing Institute of Microbiology and Epidemiology, China. His research focused on bacterial evolution of pathogenesis, human microbiota and health. He has published more than 300 papers in peer-reviewed journals, including New England Journal of Medicine, Science, Nature Genetics,Nature Communications,Cell Metabolism, ISME J., PNAS, Clinical Infectious Diseases etc. These papers have been widely cited (more than 27,000 times) by the international colleagues with H-index of 72. He is the section editor for PLOS NTD, Vice editor-in-chief for Zoonoses, Microbiologica Sinica, Chinese Journal of Preventive Medicine, Chinese Journal of Zoonosis.
报告题目:
肠道菌群可能会“思考”
Gut microbiota could “think”
报告摘要:
最近的研究显示了一种新兴且迷人的可能性,即我们的肠道菌群具有感知、处理甚至响应环境刺激的能力。现在已经越来越清楚,肠道微生物不仅可以影响其宿主的生理、代谢和免疫功能,还可以在调节宿主的行为和大脑功能方面发挥关键作用。在这份报告中,我们将讨论肠脑轴研究的最新突破,并探讨肠道微生物作为各种神经精神疾病的新型治疗靶点的潜力。我们将深入研究调控肠道微生物与大脑之间通信的基本机制,包括肠道微生物代谢物、免疫信号分子和迷走神经的作用。此外,我们还将介绍一些最有前途的肠道微生物干预技术,如粪菌移植和益生菌,以及它们的潜在局限和挑战。最后,我们将讨论这个充满希望的领域的未来展望,这可能为肠脑相关疾病的治疗提供新的策略。总体而言,肠道菌群与大脑轴的研究正在开启一种新范式,用于理解宿主-微生物相互作用的复杂性,并可能引领个性化医学的新时代。
Recent research has shown an emerging and fascinating possibility that our gut microbiota has an ability to sense, process, and even respond to environmental cues. It is now becoming increasingly clear that gut microbes could not only influence their host’s physiological, metabolic and immunological functions, but also play a critical role in regulating host behavior and brain function. In this report, we will discuss the latest breakthroughs in the gut-brain axis research and explore the potential of gut microbiota as a novel therapeutic target for various neuropsychiatric disorders. We will further examine the underlying mechanisms that govern the communication between gut microbiota and the brain, including the role of gut microbial metabolites, immune signaling molecules, and the vagus nerve. In addition, we will introduce some of the most promising techniques for manipulating gut microbiota, such as fecal microbiota transplantation and probiotics, as well as their potential limitations and challenges. Finally, we will discuss the future perspectives in this promising field, which may pave the way for developing new therapeutic strategies for gut-brain-related diseases. Overall, the ongoing research into the gut microbiota-brain axis has opened up a new paradigm for understanding the complexity of host-microbe interactions and may lead to a new era of personalized medicine.
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杨瑞馥,博士,军事医学科学院微生物流行病研究所研究员,国家自然科学基金杰出青年基金获得者。主要从事细菌菌基因组学、进化与致病机制和微生物法医学基础数据库的研究,以及检验新技术的研究。近年来,在New England Journal of Medicine、Science、Nature Genetics、Cell Metabolism,PNAS、CID、MBE等杂志发表学术SCI论文300余篇,被引27000余次,H因子72 (Google Scholar);担任《Zoonoses》、《微生物学学报》、《人兽共患病学报》和《中华预防医学杂志》副主编;近年来,获国家科技发明二等奖一项,并已成功转化。
Dr. Ruifu Yang, professor, from Beijing Institute of Microbiology and Epidemiology, China. His research focused on bacterial evolution of pathogenesis, human microbiota and health. He has published more than 300 papers in peer-reviewed journals, including New England Journal of Medicine, Science, Nature Genetics,Nature Communications,Cell Metabolism, ISME J., PNAS, Clinical Infectious Diseases etc. These papers have been widely cited (more than 27,000 times) by the international colleagues with H-index of 72. He is the section editor for PLOS NTD, Vice editor-in-chief for Zoonoses, Microbiologica Sinica, Chinese Journal of Preventive Medicine, Chinese Journal of Zoonosis.
报告题目:
肠道菌群可能会“思考”
Gut microbiota could “think”
报告摘要:
最近的研究显示了一种新兴且迷人的可能性,即我们的肠道菌群具有感知、处理甚至响应环境刺激的能力。现在已经越来越清楚,肠道微生物不仅可以影响其宿主的生理、代谢和免疫功能,还可以在调节宿主的行为和大脑功能方面发挥关键作用。在这份报告中,我们将讨论肠脑轴研究的最新突破,并探讨肠道微生物作为各种神经精神疾病的新型治疗靶点的潜力。我们将深入研究调控肠道微生物与大脑之间通信的基本机制,包括肠道微生物代谢物、免疫信号分子和迷走神经的作用。此外,我们还将介绍一些最有前途的肠道微生物干预技术,如粪菌移植和益生菌,以及它们的潜在局限和挑战。最后,我们将讨论这个充满希望的领域的未来展望,这可能为肠脑相关疾病的治疗提供新的策略。总体而言,肠道菌群与大脑轴的研究正在开启一种新范式,用于理解宿主-微生物相互作用的复杂性,并可能引领个性化医学的新时代。
Recent research has shown an emerging and fascinating possibility that our gut microbiota has an ability to sense, process, and even respond to environmental cues. It is now becoming increasingly clear that gut microbes could not only influence their host’s physiological, metabolic and immunological functions, but also play a critical role in regulating host behavior and brain function. In this report, we will discuss the latest breakthroughs in the gut-brain axis research and explore the potential of gut microbiota as a novel therapeutic target for various neuropsychiatric disorders. We will further examine the underlying mechanisms that govern the communication between gut microbiota and the brain, including the role of gut microbial metabolites, immune signaling molecules, and the vagus nerve. In addition, we will introduce some of the most promising techniques for manipulating gut microbiota, such as fecal microbiota transplantation and probiotics, as well as their potential limitations and challenges. Finally, we will discuss the future perspectives in this promising field, which may pave the way for developing new therapeutic strategies for gut-brain-related diseases. Overall, the ongoing research into the gut microbiota-brain axis has opened up a new paradigm for understanding the complexity of host-microbe interactions and may lead to a new era of personalized medicine.