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重庆大学医学院 School of Medicine Chongqing University
研究员 Research Fellow
黄锐,重庆大学医学院神经智能中心研究员,博士生导师。博士毕业于浙江大学,并在该校进行了博士后研究。研究专注于代谢调控的神经生物学机制,涵盖了大脑对食物中各种营养物质的感知、信号整合和传递,以及对外周代谢器官的调控。以第一作者或者通讯作者在Cell Research, Molecular Cell, eLife, Autophagy等杂志发表多篇论文,最近揭示的半胱氨酸调控代谢的工作被Cell Research以研究亮度予以报道,也被新华社等国内新闻机构关注和报道。
Huang Rui is a researcher and doctoral supervisor at the Neurointelligence Center of the School of Medicine, Chongqing University. He obtained his doctoral degree from Zhejiang University and conducted postdoctoral research at the same institution. His research focuses on the neurobiological mechanisms of metabolic regulation, including the perception, signal integration and transmission of various nutrients in the brain, as well as the regulation of peripheral metabolic organs. As the first author or corresponding author, he has published multiple papers in journals such as Cell Research, Molecular Cell, eLife, and Autophagy. The recent work on the regulatory role of cysteine in metabolism has been highlighted by Cell Research and received attention and coverage from domestic news agencies, including Xinhua News Agency.
报告题目:
高蛋白饮食下的神经代谢调控机制
Neuronal mechanisms of metabolic regulation under a high-protein diet
报告摘要:
肥胖问题对人们的健康构成了威胁,需要安全有效的治疗策略。在这里,我们发现高蛋白饮食显著减少果蝇的体脂存储,其中主要归因于膳食中半胱氨酸的摄入。在机制上,膳食中的半胱氨酸增加了一种神经肽FMRFamide(FMRFa)的产生。FMRFa通过其相应的受体(FMRFaR)同时促进能量消耗和抑制摄食,两者都有助于减脂效应。在脂肪体内,FMRFa信号通过增加蛋白激酶A(PKA)和脂肪酶活性促进脂解作用。在甜味感知的味觉神经元中,FMRFa信号抑制了食欲感知,从而降低食物摄入。我们还证明了膳食中的半胱氨酸在小鼠中通过一种哺乳动物RFamide肽类神经肽(neuropeptide FF,NPFF)信号传递发挥类似的作用。此外,膳食中的半胱氨酸或FMRFa/NPFF的给药在果蝇和小鼠中提供了对代谢应激的保护作用,且没有行为异常。因此,我们的研究揭示了一种潜在的用于开发治疗肥胖和相关代谢性疾病的安全有效疗法的新靶点。
Obesity imposes a global health threat and calls for safe and effective therapeutic options. Here, we found that protein-rich diet significantly reduced body fat storage in fruit flies, which was largely attributed to dietary cysteine intake. Mechanistically, dietary cysteine increased the production of a neuropeptide FMRFamide (FMRFa). Enhanced FMRFa activity simultaneously promoted energy expenditure and suppressed food intake through its cognate receptor (FMRFaR), both contributing to the fat loss effect. In the fat body, FMRFa signaling promoted lipolysis by increasing PKA and lipase activity. In sweet-sensing gustatory neurons, FMRFa signaling suppressed appetitive perception and hence food intake. We also demonstrated that dietary cysteine worked in a similar way in mice via neuropeptide FF (NPFF) signaling, a mammalian RFamide peptide. In addition, dietary cysteine or FMRFa/NPFF administration provided protective effect against metabolic stress in flies and mice without behavioral abnormalities. Therefore, our study reveals a novel target for the development of safe and effective therapies against obesity and related metabolic diseases.
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黄锐,重庆大学医学院神经智能中心研究员,博士生导师。博士毕业于浙江大学,并在该校进行了博士后研究。研究专注于代谢调控的神经生物学机制,涵盖了大脑对食物中各种营养物质的感知、信号整合和传递,以及对外周代谢器官的调控。以第一作者或者通讯作者在Cell Research, Molecular Cell, eLife, Autophagy等杂志发表多篇论文,最近揭示的半胱氨酸调控代谢的工作被Cell Research以研究亮度予以报道,也被新华社等国内新闻机构关注和报道。
Huang Rui is a researcher and doctoral supervisor at the Neurointelligence Center of the School of Medicine, Chongqing University. He obtained his doctoral degree from Zhejiang University and conducted postdoctoral research at the same institution. His research focuses on the neurobiological mechanisms of metabolic regulation, including the perception, signal integration and transmission of various nutrients in the brain, as well as the regulation of peripheral metabolic organs. As the first author or corresponding author, he has published multiple papers in journals such as Cell Research, Molecular Cell, eLife, and Autophagy. The recent work on the regulatory role of cysteine in metabolism has been highlighted by Cell Research and received attention and coverage from domestic news agencies, including Xinhua News Agency.
报告题目:
高蛋白饮食下的神经代谢调控机制
Neuronal mechanisms of metabolic regulation under a high-protein diet
报告摘要:
肥胖问题对人们的健康构成了威胁,需要安全有效的治疗策略。在这里,我们发现高蛋白饮食显著减少果蝇的体脂存储,其中主要归因于膳食中半胱氨酸的摄入。在机制上,膳食中的半胱氨酸增加了一种神经肽FMRFamide(FMRFa)的产生。FMRFa通过其相应的受体(FMRFaR)同时促进能量消耗和抑制摄食,两者都有助于减脂效应。在脂肪体内,FMRFa信号通过增加蛋白激酶A(PKA)和脂肪酶活性促进脂解作用。在甜味感知的味觉神经元中,FMRFa信号抑制了食欲感知,从而降低食物摄入。我们还证明了膳食中的半胱氨酸在小鼠中通过一种哺乳动物RFamide肽类神经肽(neuropeptide FF,NPFF)信号传递发挥类似的作用。此外,膳食中的半胱氨酸或FMRFa/NPFF的给药在果蝇和小鼠中提供了对代谢应激的保护作用,且没有行为异常。因此,我们的研究揭示了一种潜在的用于开发治疗肥胖和相关代谢性疾病的安全有效疗法的新靶点。
Obesity imposes a global health threat and calls for safe and effective therapeutic options. Here, we found that protein-rich diet significantly reduced body fat storage in fruit flies, which was largely attributed to dietary cysteine intake. Mechanistically, dietary cysteine increased the production of a neuropeptide FMRFamide (FMRFa). Enhanced FMRFa activity simultaneously promoted energy expenditure and suppressed food intake through its cognate receptor (FMRFaR), both contributing to the fat loss effect. In the fat body, FMRFa signaling promoted lipolysis by increasing PKA and lipase activity. In sweet-sensing gustatory neurons, FMRFa signaling suppressed appetitive perception and hence food intake. We also demonstrated that dietary cysteine worked in a similar way in mice via neuropeptide FF (NPFF) signaling, a mammalian RFamide peptide. In addition, dietary cysteine or FMRFa/NPFF administration provided protective effect against metabolic stress in flies and mice without behavioral abnormalities. Therefore, our study reveals a novel target for the development of safe and effective therapies against obesity and related metabolic diseases.