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School of Medicine, University of Tokyo and RIKEN Center for Biosystems Dynamics Research (BDR)/东京大学医学院、理化研究所生物系统动力学研究中心(BDR)
Hiroki R. Ueda is a professor at the Graduate School of Medicine, The University of Tokyo. He obtained his Bachelor's degree from the Faculty of Medicine at the University of Tokyo in 2000, and in 2004, he completed his Ph.D. at the same institution. In 2003, he was appointed as a team leader at RIKEN. Subsequently, in 2013, he assumed the position of full professor at the Graduate School of Medicine, The University of Tokyo. In 2016, Ueda made a groundbreaking discovery by identifying the sleep-promoting kinases, CaMKIIalpha and CaMKIIbeta. This finding led him to propose the phosphorylation hypothesis of sleep, which suggests that the phosphorylation-dependent regulation of the Ca2+-dependent hyperpolarization pathway underlies the regulation of sleep homeostasis in mammals. Furthermore, in 2018, he made another significant breakthrough by identifying the first essential genes of REM sleep, specifically muscarinic receptors M1 and M3. To further expedite his research endeavors, Ueda has pioneered innovative methods such as whole-brain and whole-body clearing and imaging techniques known as CUBIC. Additionally, he has contributed to the field of genetics by inventing next-generation mammalian genetic tools, including Triple-CRISPR and ES-mice methods. These advancements enable the streamlined production and analysis of knockout (KO) and knock-in (KI) mice without the need for traditional crossing methods.
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Hiroki R. Ueda is a professor at the Graduate School of Medicine, The University of Tokyo. He obtained his Bachelor's degree from the Faculty of Medicine at the University of Tokyo in 2000, and in 2004, he completed his Ph.D. at the same institution. In 2003, he was appointed as a team leader at RIKEN. Subsequently, in 2013, he assumed the position of full professor at the Graduate School of Medicine, The University of Tokyo. In 2016, Ueda made a groundbreaking discovery by identifying the sleep-promoting kinases, CaMKIIalpha and CaMKIIbeta. This finding led him to propose the phosphorylation hypothesis of sleep, which suggests that the phosphorylation-dependent regulation of the Ca2+-dependent hyperpolarization pathway underlies the regulation of sleep homeostasis in mammals. Furthermore, in 2018, he made another significant breakthrough by identifying the first essential genes of REM sleep, specifically muscarinic receptors M1 and M3. To further expedite his research endeavors, Ueda has pioneered innovative methods such as whole-brain and whole-body clearing and imaging techniques known as CUBIC. Additionally, he has contributed to the field of genetics by inventing next-generation mammalian genetic tools, including Triple-CRISPR and ES-mice methods. These advancements enable the streamlined production and analysis of knockout (KO) and knock-in (KI) mice without the need for traditional crossing methods.